Data Extensions is the term Marketing Cloud uses for an audience. The following wiki explains how to create a Data Extension. It's important to note that despite whoever creates the Data Extensions it's the sender's responsibility to re'Start' it before each send.
Learn all about Reporting in the IOS Salesforce. Find templates of common populations available to clone with the option of further customizing and familiarize yourself with our data dictionary to better understand data points that can be leveraged.